JACC: Heart Failure

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EDITOR-IN-CHIEF ,Christopher M. O’Connor, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA,EXECUTIVE EDITOR ,Mona Fiuzat, PharmD ,,Duke University Medical Center, Durham, NC, USA,DEPUTY EDITORS ,JoAnn Lindenfeld, MD ,,Vanderbilt Heart and Vascular Institute, Nashville, TN, USA, ,Joseph G. Rogers, MD ,,Duke University School of Medicine, Durham, NC, USA,GUEST EDITORS-IN-CHIEF ,John R. Teerlink, MD ,,San Francisco VA Medical Center, San Francisco, CA, USA, ,Barry H. Greenberg, MD ,,University of California-San Diego Medical Center, La Jolla, CA, USA,STATISTICAL EDITOR ,Scott D. Barnett, PhD, MSPH ,,Inova Heart and Vascular Institute, Falls Church, VA, USA,DIVISIONAL SENIOR DIRECTOR, PUBLISHER ,Justine Varieur, MA ,,American College of Cardiology, Washington, DC, USA,EXECUTIVE MANAGING EDITOR ,Monica R. Payne-Emmerson, MS ,,American College of Cardiology, Washington, DC, USA,MANGING EDITOR ,Steven Glaros, MA ,,American College of Cardiology, Washington, DC, USA,EDITORIAL ASSISTANT ,Alison Beale, BS ,,American College of Cardiology, Washington, DC, USA,WEB MANAGER, DIGITAL PUBLISHING ,Elizabeth Bradtke, BA ,,American College of Cardiology, Washington, DC, USA,SOCIAL MEDIA COORDINATOR ,Tamika Edaire, BS ,,American College of Cardiology, Washington, DC, USA,EDITORS-IN-CHIEF , ,,,JACC ,Valentin Fuster, MD, PhD ,,Mount Sinai Health System, New York, NY, USA,JACC: Cardiovascular Interventions ,David J. Moliterno, MD ,,University of Kentucky, Lexington, KY, USA,JACC: Cardiovascular Imaging ,Y. Chandrashekhar, MD, DM ,,University of Minnesota/VAMC, Minneapolis, MN, USA,JACC: Clinical Electrophysiology ,Kalyanam Shivkumar, MD, PhD ,,UCLA Cardiac Arrhythmia Center, UCLA Health System, Los Angeles, CA, USA,JACC: Basic To Translational Science ,Douglas L. Mann, MD ,,Washington University Medical School, St. Louis, MO, USA,JACC: Case Reports ,Julia Graspa, MD, PhD ,,Barts Health NHS Trust, London, United Kingdom,JACC: Cardio-Oncology ,Bonnie Ky, MD, MSCE ,,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA,ASSOCIATE EDITORS ,Martin R. Cowie, MD ,,National Heart & Lung Institute, London, United Kingdom, ,G. Michael Felker, MD, MHS ,,Duke Clinical Research Institute, Durham, NC, USA, ,James L. Januzzi, Jr., MD ,,Massachusetts General Hospital, Boston, MA, USA, ,Peter S. Pang, MD ,,Indiana University, Indianapolis, IN, USA, ,Hector O. Ventura, MD ,,Ochsner Medical Institute, New Orleans, LA, USA, ,David J. Whellan, MD, MHS ,,Jefferson Medical College, Philadelphia, PA, USA,INTERIM ASSOCIATE EDITORS ,Tariq Ahmad, MD, MPH ,,Yale University School of Medicine, New Haven, CT, USA, ,Maria Rosa Costanzo, MD ,,Midwest Heart Specialist, Naperville, IL, USA, ,Nasiren E. Ibrahim, MD, ,,Massachusetts General Hospital, Boston, MA, US, ,Mitchell Psotka, MD, PhD ,,Inova Heart &Vascular Institute, Falls Church, VA, USA,INTERNATIONAL ADVISORY BOARD ,Dan Atar, MD, PhD ,,Oslo University Hospital Ullevål, Oslo, Norway, ,M. Cecilia Bahit, MD ,, INECO Neurociencias, Santa Fe, Argentina, ,Antoni Bayés-Genis, MD, PhD ,,Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ,Edimar Bocchi, MD, PhD ,,Heart Institute (InCor), São Paulo University Medical School, São Paulo, Brazil, ,Diana Bonderman, MD ,,Medical University of Vienna, Vienna, Austria, ,Myeong Chan Cho, MD, PhD ,,Chungbuk National University Hospital, Cheongju, Korea, ,Chern-En Chiang, MD, PhD ,,Taipei Veterans General Hospital, Taipei, Taiwan, ,John G. F. Cleland, MD ,,University of Glasgow, Glasgow, United Kingdom, ,Alain Cohen-Solal, MD ,,Lariboisiére Hospital, Paris, France, ,Michele Emdin, MD, PhD ,,Fondazione Toscana G. Monasterio, Pisa, Italy, ,Justin A. Ezekowitz, MBBCh, MSc ,,Canadian VIGOUR Centre, University of Alberta, Alberta, Canada, ,Marco Guazzi, MD ,,University of Milano, IRCCS Policlinico San Donato, Milan, Italy, ,Johan Lassus, MD, PhD ,,Helsinki University and Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland, ,Chern-En Chiang, MD, PhD ,,Taipei Veterans General Hospital, Taipei, Taiwan, ,Basil Lewis, MD ,,Cardiovascular Clinical Research Institute, Lady Davis Carmel Medical Center, Haifa, Israel, ,Vojtech Melenovsky, MD, PhD ,,Institute for Clinical and Experimental Medicine?IKEM, Prague, Czech Republic, ,Olaf Oldenburg, MD ,,Heart and Diabetes Center North Rhine-Westphalia, Bad Oeyenhausen, Germany, ,Ali Oto, MD ,,Hacettepe University School of Medicine, Ankara, Turkey, ,Mark Petrie, MD ,,Glasgow, United Kingdom, ,Burkert Pieske, MD ,,CharitéCampus Virchow Klinikum, Berlin, Germany, ,Marwan Refaat, MD, PhD ,,American University of Beirut Faculty of Medicine and Medical Center, Beirut, Lebannon, ,A. Mark Richards, MD, PhD ,,Cardiovascular Research Institute, National University Health System, Singapore, ,Naoki Sato, MD ,,Nippon Medical School, Musashi-Kosugi Hospital, Kanagawa, Japan, ,Richard W. Troughton, MBChB ,,University of Otago, Christchurch, New Zealand, ,Hiroyuki Tsutsui, MD, PhD ,,Kyusyu University, Fukuoka, Japan, ,Klaus Witte, MD ,,University of Leeds, Leeds, United Kingdom, ,Faïez Zannad, MD, PhD ,,Inserm, Université de Lorraine and CHU-Nancy, Nancy, France,SENIOR CONSULTING EDITORS ,Paul W. Armstrong, MD ,,Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada, ,Eugene Braunwald, MD ,,Brigham and Women's Hospital, Boston, MA, USA, ,Michael R. Bristow, MD, PhD ,,University of Colorado Anschutz Medical Campus, Aurora CO USA, ,John C. Burnett, Jr., MD ,,Mayo Clinic, Rochester, MN, USA, ,Javed Butler, MD, MPH, MBA ,,University of Mississippi Medical Center, Jackson, MS, USA, ,Peter. E. Carson, MD ,,Washington VA Medical Center, Washington, DC, USA, ,Maria Rosa Costanzo, MD ,,Midwest Heart Specialists, Naperville, IL, USA, ,James P. Daubert, MD ,,Duke University Health System, Durham, NC, USA, ,Christopher deFilippi, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Gerasimos Filippatos, MD ,,Athens University Hospital Attikon, Athens, Greece, ,Stephen S. Gottlieb, MD ,,University of Maryland School of Medicine, Baltimore, MD, USA, ,Dalane W. Kitzman, MD ,,Wake Forest School of Medicine, Winston-Salem, NC, USA, ,Peter P. Liu, MD ,,Ottawa Heart Institute, Ottawa, Ontario, Canada, ,Aldo P. Maggioni, MD ,,ANMCO Research Center, Florence, Italy, ,John J. McMurray, MD, PhD ,,University of Glasgow, Glasgow, United Kingdom, ,Carmelo A. Milano, MD ,,Duke University Medical Center, Durham, NC, USA, ,Alan B. Miller, MD ,,University of Florida Health Sciences Center, Jacksonville, FL, USA, ,Douglas L. Packer, MD ,,Mayo Clinic, Rochester, MN, USA, ,Ileana Piña, MD, MPH ,,Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, USA, ,Bertram Pitt, MD ,,University of Michigan School of Medicine, Ann Arbor, MI, USA, ,Piotr Ponikowski, MD, PhD ,,Center for Heart Diseases, Military Hospital, Wroclaw, Poland, ,Mark S. Slaughter, MD ,,University of Louisville, Louisville, KY, USA, ,Randall C. Starling, MD, MPH ,,Kaufman Center for Heart Failure, Cleveland Clinic, Cleveland, OH, USA, ,Clyde W. Yancy, MD, MSc ,,Northwestern University, Feinberg School of Medicine, Chicago, OH, USA,EDITORIAL CONSULTANTS ,Keith D. Aaronson, MD, MS ,,University of Michigan Medical Center, Ann Arbor, MI, USA, ,William T. Abraham, MD ,,Ohio State University Division of Cardiovascular Medicine, Columbus, OH, USA, ,Deepak Acharya, MD, MSPH ,,University of Alabama at Birmingham, Birmingham, AL, USA, ,Tariq Ahmad, MD, MPH ,,Yale University School of Medicine, New Haven, CT, USA, ,Charles Alexander, MD ,,Alexander Associate LLC, Gwynedd Valley, PA, USA, ,Amrut Ambardekar, MD ,,University of Colorado Anschutz Medical Campus, Aurora, CO, USA, ,Inder Anand, MD, PhD ,,University of Minnesota, Department of Cardiology, Minneapolis, MN, USA, ,Brett Atwater, MD ,,Duke University Medical Center, Durham, NC, USA, ,Bradley A. Bart, MD ,,Hennepin County Medical Center, Minneapolis, MN, USA, ,Emma J. Birks, MRCP, PhD ,,University of Louisville School of Medicine, Louisville, KY, USA, ,Barry Borlaug, MD ,,Mayo Clinic, Rochester, MN, USA, ,Biykem Bozkurt, MD ,,Baylor College of Medicine, Houston, TX, USA, ,Horng H. Chen, MBBCh ,,Mayo Clinic, Rochester, MN, USA, ,Robert Cole, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Sean P. Collins, MD, MSc ,,Vanderbilt University Medical Center, Nashville, TN, USA, ,Lauren Cooper, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Jennifer A. Cowger, MD, MS ,,Henry Ford Hospital, Detroit, MI, USA, ,Kevin Damman, MD, PhD ,,University of Groningen, University Medical Center Groningen, Groningen, the Netherlands, ,Todd F. Dardas, MD, MS ,,University of Washington, Seattle, WA, USA, ,Ersilia DeFilippis, MD ,,New York Presbyterian-Columbia University Irving Medical Center, New York, NY, USA, ,Eugene DePasquale, MD ,,UCLA Medical Center, Los Angeles, CA, USA, ,Adam DeVore, MD, MHS ,,Duke University Medical Center, Durham, NC, USA, ,Thomas Di Salvo, MD, MPH, MBA ,,Medical University of South Carolina, Charleston, SC, USA, ,Stavros G. Drakos, MD, PhD ,,Utah Cardiac Transplant Program, Salt Lake City, UT, USA, ,Mark H. Drazner, MD ,,University of Texas Southwestern Medical Center, Dallas, TX, USA, ,Peter Eckman, MD ,,Minneapolis Heart Institute, Minneapolis, MN, USA, ,Howard J. Eisen, MD ,,Drexel University College of Medicine, Philadelphia, PA, USA, ,Uri Elkayam, MD ,,University of Southern California Keck School of Medicine, Los Angeles, CA, USA, ,James C. Fang, MD ,,University of Utah School of Medicine, Salt Lake City, UT, USA, ,Arthur M. Feldman, MD, PhD ,,Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA, ,Hanna K. Gaggin, MD, MPH ,,Massachusetts General Hospital, Boston, MA, USA, ,Jalal K. Ghali, MD ,,Morehouse School of Medicine, Atlanta, GA, USA, ,Michael M. Givertz, MD ,,Brigham and Women's Hospital, Boston, MA, USA, ,Sarah Goodlin, MD ,,Portland Veterans Affairs Medical Center, Portland, OR, USA, ,Sheldon Gottlieb, MD ,,Johns Hopkins University, Baltimore, MD, USA, ,Jennifer Green, MD ,,Duke Clinical Research, Institute, Durham, NC, USA, ,Garrie J. Haas, MD ,,Ohio State University Medical Center, Columbus, OH, USA, ,Shelley Hall, MD ,,Baylor Scott & White Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX, USA, ,Joshua M. Hare, MD ,,University of Miami Miller School of Medicine, Miami, FL, USA, ,Paul A. Heidenreich, MD, MS ,,Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA, ,Adrian F. Hernandez, MD, MHS ,,Duke University School of Medicine, Durham, NC, USA, ,Ray E. Hershberger, MD ,,Wexner Medical Center, Ohio State University, Columbus, OH, USA, ,J. Thomas Heywood, MD ,,Scripps Clinic, La Jolla, CA, USA, ,Jonathan Howlett, MD ,,University of Calgary, Calgary, Alberta, Canada, ,Nasrien Ibrahim, MD ,,Massachusetts General Hospital, Boston, MA, USA, ,Corrine Jurgens, PhD, RN, ANP ,,School of Nursing, Stony Brook University, Stony Brook, NY, USA, ,David Kao, MD ,,University of Colorado School of Medicine, Aurora, CO, USA, ,Stuart D. Katz, MD ,,New York University Langone Health, New York, NY, USA, ,David M. Kaye, MBBS, PhD ,,Baker IDI Heart and Diabetes Research Institute, Melbourne, Australia, ,Patricia Kelly, MD ,,Montana Heart Institute, Billings, MT, USA, ,Michel Khouri, MD ,,Duke University School of Medicine, Durham, NC, USA, ,Marvin A. Konstam, MD ,,Tufts Medical Center, Boston, MA, USA, ,Selim R. Krim, MD ,,Oschner Heart and Vascular Institute, Oschner Clinic Foundation, New Orleans, LA, USA, ,David E. Lanfear, MD ,,Henry Ford Hospital, Detroit, MI, USA, ,Carl Lavie, MD ,,John Ochsner Heart and Vascular Institute, Ochsner Clinical School University of Queensland School of Medicine, New Orleans, LA, USA, ,Carl V. Leier, MD ,,College of Medicine and Public Health, Ohio State University, Columbus, OH, USA, ,Wayne C. Levy, MD ,,University of Washington, Seattle, WA, USA, ,Eldrin F. Lewis, MD, MPH ,,Brigham and Women's Hospital, Boston, MA, USA, ,Gregory D. Lewis, MD ,,Massachusetts General Hospital, Boston, MA, USA, ,Carlo Lombardi, MD ,,University of Brescia, Brescia, Italy, ,Lars H. Lund, MD, PhD ,,Karolinska Institute, Stockholm, Sweden, ,Michael Mack, MD ,,Baylor Scott & White Health, Plano, TX, USA, ,Alan S. Maisel, MD ,,Veterans Affairs San Diego Healthcare System, San Diego, CA, USA, ,Donna Mancini, MD ,,Icahn School of Medicine at Mount Sinai, New York, NY, USA, ,Douglas L. Mann, MD ,,Washington University Medical School, St. Louis, MO, USA, ,Kenneth B. Margulies, MD ,,University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA, ,Colleen K. McIlvennan, DNP, ANP ,,University of Colorado School of Medicine, Aurora, CO, USA, ,Dennis M. McNamara, MD, MS ,,Heart and Vascular Institute, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, ,Mandeep R. Mehra, MD ,,Brigham and Women's Hospital, Heart and Vascular Center, Boston, MA, USA, ,Robert J. Mentz, MD ,,Duke Clinical Research Institute, Durham, NC, USA, ,Marco Metra, MD, PhD ,,Uniiversity of Brescia, Brescia, Italy, ,Leslie W. Miller, MD ,,Morton Plant Hospital, Clearwater, FL, USA, ,Wayne Miller, MD, PhD ,,Mayo Clinic, Rochester, MN, USA, ,Wilfried Mullens, MD, PhD ,,Ziekenhuis Oost-Limburg, Genk, Belgium, ,Robert Lee Page, III, PharmD, MSPH ,,University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA, ,Kishan Parikh, MD ,,Duke Clinical Research Institute, Durham, NC, USA, ,Chetan B. Patel, MD ,,Duke University Medical Center, Durham, NC, USA, ,Jonathan P. Piccini, MD, MHS ,,Duke Clinical Research Institute, Durham, NC, USA, ,Sean P. Pinney, MD ,,Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Hospital, New York, NY, USA, ,Mitchell Psotka, MD, PhD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Paul B. Rosenberg, MD ,,Duke University Medical Center, Durham, NC, USA, ,Stuart D. Russell, MD ,,Duke University Medical Center, Durham, NC, USA, ,Douglas B. Sawyer, MD, PhD ,,Maine Medical Center, Portland, ME, USA, ,Douglas D. Schocken, MD ,,Duke University School of Medicine, Durham, NC, USA, ,Marc J. Semigran, MD ,,MyoKardia, South San Francisco, CA, USA, ,Keyur Shah, MD ,,Virginia Commonwealth University, Richmond, VA, USA, ,Abhinav Sharma, MD ,,McGill University, Montreal, Canada, ,Marc A. Silver, MD ,,Advocate Christ Medical Center, Oak Lawn, IL, USA, ,Shashank S. Sinha, MD, MSc ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Josef Stehlik, MD, MPH ,,University of Utah School of Medicine, Salt Lake City, UT, USA, ,Lynne Stevenson, MD ,,Vanderbilt University Medical Center, Nashville, TN, USA, ,W.H. Wilson Tang, MD ,,Cleveland Clinic, Cleveland, OH, USA, ,Ryan J. Tedford, MD ,,Medical University of South Carolina, Charleston, SC, USA, ,Jeffrey M. Testani, MD, MTR ,,Yale University School of Medicine, New Haven, CT, USA, ,Jeffrey J. Teuteberg, MD ,,Stanford University Medical Center, Stanford, CA, USA, ,Muthiah Vaduganathan, MD, MPH ,,Brigham and Women's Hospital, Boston, MA, USA, ,Orly Vardeny, PharmD, MS ,,University of Minnesota Medical School, Minneapolis, MN, USA, ,Eric J. Velazquez, MD ,,Yale University School of Medicine, New Haven, CT, USA, ,Adriaan Voors, MD, PhD ,,University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands, ,Mary N. Walsh, MD ,,St. Vincent Heart Center, Indianapolis, IN, USA, ,Eugene E. Wolfel, MD, MA ,,University of Colorado School of Medicine, Aurora, CO, USA, ,James B. Young, MD, PhD ,,Cleveland Clinic Foundation, Cleveland, OH, USA, ,Michael R. Zile, MD, PhD ,,Medical University of South Carolina, Charleston, SC, USA,CME/MOC/ECME MEDIA EDITORS ,Robert Cole, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Lauren Cooper, MD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Kishan Parikh, MD ,,Duke Clinical Research Institute, Durham, NC, USA, ,Abhinav Sharma, MD ,,McGill University, Montreal, Canada,SOCIAL MEDIA EDITORS ,Shashank S. Sinha, MD, MSc ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Muthiah Vaduganathan, MD, MPH ,,Brigham and Women's Hospital, Boston, MA, USA,SOCIAL MEDIA CONSULTANTS ,Ersilia M. DeFilippis, MD ,,Columbia University Irving Medical Center, New York, NY, USA, ,Melvin Ray Echols, MD ,,Morehouse School of Medicine, Atlanta, GA, USA, ,Mitchell Psotka, MD, PhD ,,Inova Heart and Vascular Institute, Falls Church, VA, USA, ,Nosheen Reza, MD ,,Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA USA, ,Holly Atkinson, MD ,,Mount Sinai Health System, New York, NY, USA,ETHICS COMMITTEE ,Richard L. Popp, MD ,,Stanford Health Care, Palo Alto, CA, USA, ,Lawrence S. Cohen, MD ,,Yale University School of Medicine, New Haven, CT, USA, ,Kim Fox, MD ,,National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK, ,Robert Frye, MD ,,Mayo Clinic Rochester, Rochester, MN, USA, ,Philip J. Landrigan, MD ,,Mount Sinai, New York, NY, USA, ,Eric N. Prystowsky, MD ,,The Care Group, LLC, Indianapolis, IN, USA,2021-2022 OFFICERS ,Athena Poppas, MD, FACC ,,President, The Miriam and Newport Hospitals, Providence, RI, USA, ,Dipti Itchhaporia, MD, FACC ,,Vice President, Hoag Memorial Hospital Presbyterian, Newport Beach, CA, USA, ,Howard "Bo" T. Walpole, Jr., MD, MBA, FACC ,,Treasurer, Northeast Georgia Health System, Gainesville, GA, USA, ,Daniel M. Philbin, Jr., MD, FACC ,,Secretary and Board of Governors Chairs, New England Heart and Vascular Institute in Manchester, NH, USA, ,Cathleen C. Gates ,,Acting American College of Cardiology (ACC) Chief Executive Officer, Washington, DC, USA,2021-2022 SCIENTIFIC PUBLICATIONS COMMITTEE(SPC) ,Viviany R. Taqueti, MD, MPH, FACC ,,Chair, Brigham and Women's Hospital, Boston, MA, USA, ,Rhonda M. Cooper-DeHoff, MD, FACC ,,University of Florida Health, Gainesville, FL, USA, ,John U. Doherty, MD, FACC ,,Jefferson University Hospitals, Philadelphia, PA, USA, ,Islam Y. Elgendy, MD, FACC ,,Weill Cornell Medicine-Qatar, Doha, Qatar, ,Prasad C. Gunasekaran, MD ,,Mercy Heart Hospital, Springfield, MO, USA, ,Fadi G. Hage, MD, FACC ,,The University of Alabama at Birmingham, Birmingham, AL, USA, ,Fred M. Kusumoto, MD, FACC ,,Mayo Clinic, Jacksonville, FL, USA, ,Renato D. Lopes, MD, PhD, FACC ,,Duke University School of Medicine, Durham, NC, USA, ,Sandra M. Oliver-McNeil, DNP, ACNP-BC ,,Wayne State University, Detroit, MI, USA, ,Syed Tanveer Rab, MBBS, MACC ,,Emory Hosptal, Atlanta, GA, USA, ,Janice B. Sibley, MS, MA ,,ACC Divisional Senior Director, Publishing, Washington, DC, USA, ,Justine Varieur Turco, MA ,,ACC Divisional Senior Director, Publishing, Washington, DC, USA