Sande's HIV/AIDS Medicine, Medical Management of AIDS 2013, 2nd Edition

Sande's HIV/AIDS Medicine

2nd Edition Medical Management of AIDS 2013

Edited by Paul Volberding, Senior Clinical Research Fellow;Marvin Sleisenger Professor and Vice Chair;Department of Medicine University of California San Francisco;San Francisco, CA, USA ; Warner Greene, Director, Gladstone Institute of Virology and Immunology; Nick and Sue Hellmann Distinguished Professor of Translational Medicine; Professor of Medicine, Microbiology and Immunology; University of California, San Francisco; San Francisco, CA ; Joep M. A. Lange, MD, Professor of Medicine; Global Health; Academic Medical Center, University of Amsterdam; Amsterdam Institute for Global Health and Development; Amsterdam; The Netherlands ; Joel E. Gallant, MD, MPH, Professor of Medicine and Epidemiology;Associate Director, Johns Hopkins AIDS Service;Division of Infectious Diseases, Department of Medicine;Johns Hopkins University School of Medicine;Baltimore, MD, USA and Nelson Sewankambo


Contents

Preface vii

Contributors ix

Acknowledgments xv

SECTION 1: Epidemiology and biology of HIV infection

1 The global epidemiology of HIV/AIDS 3

Irum Zaidi, Kevin M De Cock

2 The origins and diversification of HIV 15

Michael Worobey, Guan-Zhu Han

3 Molecular biology of HIV: implications for new therapies 25

Warner C Greene, B Matija Peterlin, Matthew H Stremlau

4 The immune response to HIV 45

Clive M Gray, Pamela Gumbi, Lycias Zembe, Mopo Radebe, Bruce Walker

5 Viral and host determinants of HIV-1 disease progression 59

Danie¨lle van Manen, Ange´lique B van ?t Wout, Hanneke Schuitemaker

6 Acute HIV infection 77

Anthony D Kelleher, David A Cooper

7 Biology of HIV-1 transmission 89

Julie Overbaugh

SECTION 2: Prevention, diagnosis, and treatment of HIV infection

8 The design of a global HIV vaccine 97

Jerome H Kim, Nelson L Michael

9 HIV prevention 113

Salim S Abdool Karim

10 Laboratory testing for HIV infection 123

James C Shepherd, Oliver Laeyendecker, Thomas C Quinn

11 Overview of antiretroviral therapy 133

Susa Coffey, Paul A Volberding

12 Development and transmission of HIV drug resistance 155

Mark A Wainberg, Gerasimos J Zaharatos

13 Pharmacology of antiretroviral drugs 169

Concepta Merry, Charles W Flexner

14 Complications resulting from antiretroviral therapy for HIV infection 177

David Nolan, Simon Mallal, Peter Reiss

SECTION 3: Diseases associated with HIV infection

15 Oral complications of HIV infection 195

John S Greenspan, Deborah Greenspan

16 Ocular manifestations of AIDS 207

James P Dunn

17 Global HIV and dermatology 219

Toby Maurer, Robert Michelleti

18 Gastrointestinal disorders in HIV including diarrhea 237

Marie-Louise C Vachon, Douglas T Dieterich

19 Primary neurological manifestation of HIV/AIDS 249

David B Clifford, Mengesha A Teshome

20 Psychiatric barriers and the international AIDS epidemic 257

Chiadi U Onyike, Andrew F Angelino,

Glenn J Treisman

21 Cardiovascular complications of HIV infection 267

Rakesh K Mishra

22 Endocrine complications of HIV infection 275

Steven A Taylor, Carl Grunfeld,

Morris Schambelan

23 Renal complications of HIV infection 287

Jula K Inrig, Lynda A Szczech,

Trevor E Gerntholtz, Paul E Klotman

24 Pneumocystis pneumonia 297

Robert J Blount, J Lucian Davis,

Laurence Huang

25 Other HIV-related pneumonias 313

John G Bartlett

26 HIV-associated tuberculosis 325

Leyla Azis, Edward C Jones-Lo´pez,

Jerrold J Ellner

27 Disseminated Mycobacterium avium complex and other atypical mycobacterial infections 349

Mark A Jacobson

28 Candida in HIV infection 359

William G Powderly

29 Cryptococcosis and other fungal infections

(histoplasmosis and coccidioidomycosis)

in HIV-infected patients 369

Kathleen R Page, Richard E Chaisson,

Merle Sande

30 Infection due to Penicillium marneffei 389

Thira Sirisanthana, Khuanchai Supparatpinyo

31 AIDS-associated toxoplasmosis 397

Pablo A Moncada, Jose G Montoya

32 Hepatitis virus infections 411

Marion G Peters, Monika Sarkar

33 Bartonella infections in HIV-infected individuals 421

Jane E Koehler

34 Management of herpesvirus infections

(cytomegalovirus, herpes simplex virus, and varicella-zoster virus) 433

W Lawrence Drew, Kim S Erlich

35 HIV-associated malignancies 455

Ronald T Mitsuyasu

36 STDs and syphilis 467

Elysia Larson, Jeffrey D Klausner

SECTION 4: Prevention and management

37 Prevention of mother-to-child transmission of HIV-1 485

Lynne M Mofenson

38 Managing HIV infection in children and adolescents 509

Elizabeth H Doby, Andrew T Pavia

39 Special issues regarding women with HIV infection 521

Ruth M Greenblatt, Monica Gandhi

40 HIV disease among substance users:

treatment issues 537

R Douglas Bruce, Frederick L Altice,

Gerald Friedland

41 The HIV-infected international traveler 551

Malcolm John

Index 561