Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

5th Edition

By Carl A. Burtis, PhD, Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT; Edward R. Ashwood, MD, Professor of Pathology, University of Utah School of Medicine, and President and CEO, ARUP Laboratories, Salt Lake City, UT and David E. Bruns, MD, Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC


Section I: Principles of Laboratory Medicine

  1. Introduction to Laboratory Medicine
  2. Selection and Analytical Evaluation of Methods - With Statistical Techniques
  3. Clinical Evaluation of Methods
  4. Evidence Based Laboratory Medicine
  5. Establishment and Use of Reference Values
  6. Preanalytical Variables and Biological Variation
  7. Specimen Collection and Processing
  8. Quality Management
  9. Section II: Analytical Techniques and Instrumentation

  10. Principles of Basic Techniques and Laboratory Safety
  11. Optical Techniques
  12. Electrochemistry and Chemical Sensors
  13. Electrophoresis
  14. Chromatography and Extraction
  15. Mass Spectrometry
  16. Enzyme and Rate Analyses
  17. Principles of Immunochemical Techniques
  18. Nucleic Acid Techniques
  19. Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
  20. Automation in the Clinical Laboratory
  21. Point-of-Care Testing
  22. Section III: Analytes

  23. Amino Acids, Peptides, and Proteins
  24. Serum Enzymes
  25. Enzymes of the Red Blood Cell
  26. Tumor Markers
  27. Kidney Function Tests
  28. Carbohydrates
  29. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
  30. Electrolytes and Blood Gases
  31. Hormones
  32. Catecholamines and Serotonin
  33. Vitamins and Trace Elements
  34. Hemoglobin, Iron, and Bilirubin
  35. The Porphyrias and Other Disorders of Porphyrin Metabolism
  36. Therapeutic Drugs and Their Management
  37. Clinical Toxicology
  38. Toxic Metals
  39. Section IV: Molecular Diagnostics and Genetics

  40. Principles of Molecular Biology
  41. Genomes and Nucleic Acid Alterations
  42. Nucleic Acid Isolation
  43. Inherited Diseases
  44. Identity Assessment
  45. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
  46. Pharmacogenetics
  47. Hematopoietic Malignancies
  48. Plasma Nucleic Acids
  49. Section V: Pathophysiology

  50. Diabetes Mellitus
  51. Cardiovascular Disease
  52. Kidney Disease
  53. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
  54. Liver Disease
  55. Gastrointestinal and Pancreatic Diseases
  56. Disorders of Bone and Mineral Metabolism
  57. Pituitary Function and Pathophysiology
  58. The Adrenal Cortex
  59. The Thyroid: Pathophysiology and Thyroid Function Testing
  60. Reproductive Endocrinology and Related Disorders
  61. Pregnancy and its Disorders
  62. Newborn Screening and Inborn Errors of Metabolism
  63. Hemostasis
  64. Section VI: Appendix

  65. Reference Information for the Clinical Laboratory