Drug Discovery and Development, Technology in Transition, 2nd Edition

Drug Discovery and Development

2nd Edition Technology in Transition

By Raymond G Hill, President, British Pharmacological Society, London, UK


Contents

SECTION 1

INTRODUCTION AND BACKGROUND

1. The development of the pharmaceutical industry

H P Rang

2. The nature of disease and the purpose of therapy

H P Rang, R G Hill

3. Therapeutic modalities

H P Rang, H LeVine, R G Hill

SECTION 2

DRUG DISCOVERY

4. The drug discovery process: general principles and some case histories

H P Rang, R G Hill

5. Choosing the project

H P Rang, R G Hill

6. Choosing the target

H P Rang, R G Hill

7. The role of information, bioinformatics and genomics

B Robson, R McBurney

8. High-throughput screening

D Cronk

9. The role of medicinal chemistry in the drug discovery process

P Beswick, A Naylor

10. DMPK optimization strategy in drug discovery

P G Ballard, P Brassil, K H Bui, H Dolgos, C Petersson, A Tunek, P J H Webborn

11. Pharmacology: its role in drug discovery

H P Rang

12. Biopharmaceuticals

H LeVine

13. Scaffolds: Small globular proteins as antibody substitutes

D Grabulovski, J Bertschinger

SECTION 3

DRUG DEVELOPMENT

14. Drug development: introduction

H P Rang, R G Hill

15. Assessing drug safety

H P Rang, R G Hill

16. Pharmaceutical developmentT Lundqvist, S Bredenberg

17. Clinical Development - Present and Future

C Keywood

18. Clinical imaging in drug development

P M Matthews

19. Intellectual property in drug discovery and development

P Grubb

20. Regulatory affairs

I Hägglöf, Å Holmgren

21. Marketing the drug

V L Lawton

SECTION 4

FACTS AND FIGURES

22. Drug discovery and development - facts and figures

H P Rang, R G Hill