Principles of investigation and diagnosis. SECTION ONE: HARD TISSUE PATHOLOGY. Disorders of development of teeth and related tissues. Dental caries. Pulpitis, apical periodontitis, resorption, hypercementosis. Gingivitis and periodonitis. Major infections of the mouth, jaws and perioral tissues. Cysts of the jaws. Odontogenic tumours and tumour-like lesions of the jaws. Non-odontogenic tumours of the jaws. Genetic, metabolic and other non-neoplastic bone diseases. Disorders of the temporomandibular joints and periarticular tissues. Self-assessment queestions and learning guides. SECTION TWO: SOFT TISSUE DISEASE. Diseases of the oral mucosa: introduction and mucosal infections. Diseases of the oral mucosa: non-infective stomatitis. Tongue disorders. Benign chronic white mucosal lesions. Oral premalignancy. Oral cancer. Neoplastic and non-neoplastic diseases of salivary glands. Common benign mucosal swellings. Soft-tissue (mesenchymal) neoplasms. Melanoma and other pigmented lesions. Self-assessment quesions and learning guides. SECTION THREE: THE MEDICALLY COMPROMISED PATIENT. Anaemias, leukaemias and lymphomas. Haemorrhagic diseases. Immunodeficiencies and HIV disease. Allergy and autoimmune disease. Cervical lymphadenopathy. Cardiovascular disease. Respiratory tract disease. Gastrointestinal and liver disease. Nutritional deficiencies. Endocrine disorders and pregnancy. Renal disease. Intellectual and physical disability and psychiatric disorders. Pain, anxiety, neurological and psychogenic disorders. Complications of systemic drug treatment. Emergencies in dental practice. Self-assessment questions and learning guides.