Genetics of Hypertension, Handbook of Hypertension Series

Genetics of Hypertension

Handbook of Hypertension Series

By Anna Dominiczak, MD, FRCP, FMedSci, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK; and John Connell, MD, FRCP, FMedSci, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK


Overview. Genetic epidemiology of hypertension. Monogenic disorders of blood pressure measurement. Genome scans in hypertension. Genetics of stroke. Genetics of pre-eclampsia. Meta-analyses in genetics: methodological considerations with a focus on the renin-angiotensin system. Genetics and genomics: impact on drug discovery and development. Adducin genes as a paradigm for functional studies. Attaching physiology to the genome. Genetic studies of inherited hypertension in the rat. Transgenic rats and hypertension. targeting in mice to study blood pressure regulation: role of the angiotensin system. Gene therapy for hypertension: a promise waiting to be fulfilled?