Foreword (P.A. Poole-Wilson). Acknowledgements. Introduction. 1. Coronary artery disease before 1920. 2. Coronary artery disease 1920-2000. 3. Coronary artery disease after 2000: Epidemiologic transitions. 4. The cholesterol controversy. 5. Food and coronary artery disease. 6. The agricultural connection. 7. Diversity, complexity and human disease. 8. Biotechnology and the marriage of university and industry. 9. Medicalization. 10. Managing medicine. Conclusions. Appendix 1: A crash course in coronary artery disease. Appendix 2: A mini-course on fats. Index.