Fetal and Neonatal Neurology and Neurosurgery, 4th Edition

Fetal and Neonatal Neurology and Neurosurgery

4th Edition

By Malcolm I. Levene, MD, FRCP, FRCPCH, FMedSc, Professor of Pediatrics and Child Health, Division of Paediatrics and Child Health, University of Leeds, Leeds General Infirmary, Leeds, UK; and Frank A. Chervenak, MD, FACOG, MMM, Given Foundation Professor and Chairman, Department of Obstetrics and Gynecology, New York Weill Cornell Medical Center, New York, NY, USA

SECTION I Structural Development of the CNS

1. The molecular basis of brain development
2. Early embryonic development of the brain
3. Development of consciousness: fetal, neonatal and maternal interactions
4. Ultrasound assessment of normal fetal brain development
5. MR imaging of the fetal central nervous system
6. Imaging the neonatal brain

SECTION II Functional Assessment of CNS Development

7. Functional assessment of the fetal CNS
8. The development of senses
9. Clinical assessment of the infant nervous system
10. Perinatal cerebral circulation
11. Cerebral blood flow and energy metabolism in the developing brain
12. EEG and evoked potentials in the neonatal period


13. Congenital structural defects of the brain
14. Genetics of neurodevelopmental anomalies
15. Antenatal assessment of CNS anomalies, including neural tube defects
16. Transvaginal fetal neuroscan
17. Epidemiology and prevention of neural tube defects

SECTION IV Hemorrhagic and Ischemic Lesions

18. Fetal brain injury and multiple pregnancies
19. Infection, inflammation and brain injury
20. Neonatal intracranial hemorrhage
21. Cerebral ischemic lesions

SECTION V Perinatal Asphyxia

22. Pathophysiology of asphyxia
23. Antenatal prediction of asphyxia
24. Intrapartum monitoring for asphyxia
25. Prediction of asphyxia with fetal gas analysis
26. The asphyxiated newborn infant
27. Neuroprotection of the fetal and neonatal brain
28. Medico-legal issues: The United Kingdom perspective
29. Malpractice issues in perinatal medicine: The United States perspective

SECTION VI Infection of the CNS

30. Toxoplasmosis
31. Congenital viral infections and the central nervous system
32. Bacterial and fungal infections

SECTION VII Metabolic Disorders

33. Inborn errors of metabolism presenting with encephalopathy

SECTION VIII Seizure Disorders

34. Seizure disorders of the neonate
35. Hypoglycemia and brain injury - when neonatal metabolic adaptation fails
36. Kernicterus

SECTION IX the Special Senses

37. Disorders of vision
38. Hearing disorders

SECTION X Disorders of the Nerve and Muscle

39. Disorders of the spinal cord, cranial and peripheral nerves
40. Neuromuscular disorders

SECTION XI Hydrocephalus and Neurosurgery

41. Fetal neurosurgical interventions
42. Neonatal hydrocephalus ? clinical assessment and non-surgical treatment
43. Neurosurgical management of hydrocephalus
44. Surgical management of neural tube defects
45. Congenital defects, vascular malformations and other lesions

SECTION XII Epidemiology of Neurologic Disability

46. The epidemiology of the cerebral palsies
47. The epidemiology of intellectual disabilities

SECTION XIII Ethical Dilemmas

48. Issues for the obstetrician
49. Issues for the neonatologist