Wall and Melzack's Textbook of Pain, 5th Edition

Wall and Melzack's Textbook of Pain

5th Edition

By Stephen McMahon, PhD, Sherrington Professor of Physiology, Director, Centre for Neuroscience Research, King's College London, UK; and Martin Koltzenburg, MD, Hononary Consultant, National Hospital for Neurology and Neurosurgery, Professor of Pain Research, Institute of Child Health/Institute of Neurology, University College London, UK


Section 1. Neurobiology of pain

1. Peripheral mechanisms of cutaneous nociception

2. Cellular and molecular properties of primary afferent neurons

3. Inflammatory mediators and modulators of pain

4. Neuroanatomical substrates of spinal nociception

5. Plasticity and pain: role of the dorsal horn

6. Representation of pain in the brain

7. Central nervous system mechanisms of pain modulation

8. Development of pain pathways and mechanisms

9. The genetics of pain

10. Animal models of pain

11. Ascending projection systems

12. Autonomic-endocrine-immune interactions in acute and chronic pain

13. Itch



Section 2. Assessment and psychology of pain

14. Emotions and psychobiology

15. Cognitive and learning aspects

16. Psychiatric disorders and pain

17. Studies of pain in human subjects

18. Pain assessment in adult patients

19. Measurement and assessment of paediatric pain

20. Assessment of pain beliefs, coping, and function

21. Hypnotic analgesia

22. The cognitive-behavioural approach to pain management

23. Pain, opiates and addiction

24. Placebo analgesia



Section 3. Pharmacology and Treatment of Pain

25. Central pharmacology of nociceptive transmission

26. Methods of therapeutic trials

27. Opiates: basic mechanisms

28. Opioids: clinical use

29. Antipyretic analgesics: basic aspects

30. NSAIDs and Coxibs: clinical use

31. Antidepressant analgesics: a systematic review and comparative study

32. Anticonvulsant medications in neuropathic pain

33. Local anaesthetic blocks and epidurals

34. Cannabinoids

35. Analgesic drugs in development

36. Supratentorial neurosurgery for the treatment of pain

37. Spinal cord and brain stimulation

38. Transcutaneous electrical nerve stimulation and acupuncture

39. Peripheral and central nervous system surgery for pain

40. Physiotherapy and pain



Section 4. Clinical states: Deep somatic tissue

41. Basic mechanisms of deep somatic pain

42. Postoperative pain and its management

43. Osteoarthritis and rheumatoid arthritis

44. Myofascial pain and fibromyalgia syndrome

45. Surgical treatment for back and neck pain

46. Low back pain

47. Repetitive strain injury



Section 5. Viscera

48. Visceral pain: basic mechanisms

49. Thorax

50. A clinical perspective on abdominal pain

51. Genitourinary pain

52. Obstetric pain



Section 6. Clinical States: Headache and facial pain

53. Acute and chronic dental and orofacial pain

54. Headache

55. Primary neurovasuclar headache

56. Tension-type headache

57. Pain in and around the eye



Section 7. Clinical states: Neuropathic pain

58. Response of nerves to injury in relation to neuropathic pain

59. Mechanisms of experimental neuropathic pain: integration from animal models

60. Central consequences of peripheral nerve damage

61. Phantom limb

62. Painful peripheral neuropathies

63. Trigeminal and glossopharyngeal neuralgia

64. Complex regional pain syndromes

65. Root disorders and arachnoiditis

66. Pain following spinal cord injury

67. Central pain

68. Pharmacological therapy for neuropathic pain



Section 8. Clinical states: Cancer pain

69. Cancer pain: causes, consequences and therapeutic opportunities

70. The assessment of cancer pain

71. Analgesic therapy and palliative care in children

72. Cancer pain: treatment overview

73. Pain control in the care of the dying



Section 9. Clinical States: Special cases

74. Pain in the elderly

75. Sex and gender differences in pain and its relief

76. Epidemiology of pain



Index