Epidemiology and Diagnosis
1. Epidemiology
2. Disease Activity Measures
3. Disease Outcome
4. Quality of Life and Economic Aspects
Pathogenesis
1. Overview of the Pathogenesis of SLE
2. Genetics
3. Hormones
4. Immunoregulation ? T Cells, B cells, and cytokines.
5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)
6. Dendritic Cells
7. Apoptosis
8. Structure and Origin of Autoantibodies
9. Animal Models
10. Genetics of murine lupus
11. Infection and autoimmunity
Mechanisms of Tissue Damage
1. Complement
2. Immune complexes
3. Antibodies
a. ANA and standardization of antibody techniques
b. Anti-DNA
c. Anti-splicesomosal ab
d. Anti-Ro/La
e. Anti-Histone
f. APL
g. Anti-neuronal
4. PMNs
5. Mechanisms of renal damage
6. Mechanisms of vascular damage
7. Nitric Oxide
Clinical Aspects of the Disease
1. Constitutional Symptoms and Fatigue
2. Skin
3. Kidney
4. Heart
5. Lung
6. GI/liver/pancreas
7. Infections
8. Blood (anti-phospholipid syndrome)
9. Nervous System
10. Overlap Syndromes
11. Ophthalmic Manifestations
12. Pregnancy
13. Fertility
14. Neo-natal lupus
15. Hereditary and Malignant Lupus-like Diseases
Treatment of the Disease
1. Non-Steroidals ? Anti-Malarials and Statins
2. Steroid Treatment
3. Cytotoxic Drug Treatment including M.M.F
4. PAPS
5. New Treatments