Systemic Lupus Erythematosus, A Companion to Rheumatology

Systemic Lupus Erythematosus

A Companion to Rheumatology

By George C. Tsokos; Caroline Gordon; and Josef S. Smolen, MD, Department of Internal Medicine, University of Vienna and Center for Rheumatic Diseases, Lainz Hospital, Vienna, Austria


Epidemiology and Diagnosis

1. Epidemiology

2. Disease Activity Measures

3. Disease Outcome

4. Quality of Life and Economic Aspects

Pathogenesis

1. Overview of the Pathogenesis of SLE

2. Genetics

3. Hormones

4. Immunoregulation ? T Cells, B cells, and cytokines.

5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)

6. Dendritic Cells

7. Apoptosis

8. Structure and Origin of Autoantibodies

9. Animal Models

10. Genetics of murine lupus

11. Infection and autoimmunity

Mechanisms of Tissue Damage

1. Complement

2. Immune complexes

3. Antibodies

a. ANA and standardization of antibody techniques

b. Anti-DNA

c. Anti-splicesomosal ab

d. Anti-Ro/La

e. Anti-Histone

f. APL

g. Anti-neuronal

4. PMNs

5. Mechanisms of renal damage

6. Mechanisms of vascular damage

7. Nitric Oxide

Clinical Aspects of the Disease

1. Constitutional Symptoms and Fatigue

2. Skin

3. Kidney

4. Heart

5. Lung

6. GI/liver/pancreas

7. Infections

8. Blood (anti-phospholipid syndrome)

9. Nervous System

10. Overlap Syndromes

11. Ophthalmic Manifestations

12. Pregnancy

13. Fertility

14. Neo-natal lupus

15. Hereditary and Malignant Lupus-like Diseases

Treatment of the Disease

1. Non-Steroidals ? Anti-Malarials and Statins

2. Steroid Treatment

3. Cytotoxic Drug Treatment including M.M.F

4. PAPS

5. New Treatments