|(With Adobe DRM, readable with Adobe Digital Editions for PCs and Macs, and on most mobile devices except Kindle)|
New to This Edition
- Focus on intramolecular actions
- Mechanisms of action richly illustrated
- Self-assessment included
- Comprehensive chapters on vitamins and biotechnological products
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms.
By David G. Watson, BSc, PhD, PGCE, Senior Lecturer in Pharmaceutical Sciences, School of Pharmacy, University of Strathclyde, Glasgow, UK